TSID Special Lecture
Title: RNA origin of sex biased immunity
Keynote speaker
Howard Y. Chang
MD, PhD., Chief Scientific Officer, Amgen
Amgen, USA
BIOGRAPHY
Dr. Howard Y. Chang is the Chief Scientific Officer and Senior Vice President for Global Research at Amgen. He is responsible for leading all aspects of discovery research.
Prior to joining Amgen, Dr. Chang led a research laboratory at Stanford University focused on deciphering regulatory information in the human genome for disease diagnosis and therapy. A physician-scientist and board-certified dermatologist, he served as Professor of Dermatology, Genetics, and Pathology at Stanford and Investigator of the Howard Hughes Medical Institute.
Dr. Chang is the winner of the Albany Prize, King Faisal Prize for Science, Lurie Prize in Biomedical Sciences, and NAS Award in Molecular Biology for discoveries of regulatory RNAs. He is an elected member of the National Academy of Sciences, National Academy of Medicine, and American Academy of Arts and Sciences. He is a serial entrepreneur having founded five biotech companies.
Dr. Chang holds a M.D. from Harvard Medical School, a Ph.D. in Biology from MIT, and an A.B. in Biochemical Sciences from Harvard University.
Top 5 selected publications
Yu, B., H.Y. Chang (2026) Long noncoding RNA regulation of immunity. Nature Immunology, 27, 16-25.
Yan, B., J. Lee, S. Srinivasan, Q. Shi, D.R. Dou, S. Davuluri, S. Nandyala, A. Woods, G. Leatherman, Y. Zhao, R.E. Reggiardo, M. Sawant, H.R. Thiam, A. Shah, D.F. Fiorentino, L.S. Chung, H.Y. Chang (2026) Autoantibody hotspots reveal origin and impact of immunogenic XIST ribonucleoprotein complex. Journal of Clinical Investigation, 136, e198291.
Dou, D.R., Y. Zhao, J.A. Belk, Y. Zhao, K.M. Casey, D.C. Chen, R. Li, B. Yu, S. Srinivasan, B.T. Abe, K. Kraft, C. Hellström, R. Sjöberg, S. Chang, A. Feng, D.W. Goldman, A.A. Shah, M. Petri, L.S. Chung, D.F. Fiorentino, E.K. Lundberg, A. Wutz, P.J. Utz, H.Y. Chang (2024) Xist ribonucleoproteins promote female sex-biased autoimmunity. Cell, 187, 733-749.
Yu, B. Y. Qi, R. Li, Q. Shi, A.T. Satpathy, H.Y. Chang (2021) B-cell specific XIST complex enforces X-inactivation and restrains atypical B cells. Cell, 184, 1790-1803
Chu, C., Q.C. Zhang, S.T. da Rocha, R.A. Flynn, M. Bharadwaj, J.M. Calabrese, T. Magnuson, E. Heard, H.Y. Chang(2015) Systematic discovery of Xist RNA binding proteins. Cell, 161, 404-416.
